Indianapolis and Washington have the lowest vaccination rate in the NFL.  They face potential competitive disadvantages.

Unvaccinated players must continue to get daily testing, wear masks and practice physical distancing. They won't be allowed to eat meals with teammates, can't participate in media or marketing activities while traveling, aren't permitted to use the sauna or steam room, and may not leave the team hotel or interact with people outside the team while traveling. Vaccinated players will not have any of those restrictions.